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In ancient times the Greeks believed that all matter beneath the moon was made of varying combinations of the four elements: Earth, Water, Fire and Air. Above the moon, matter was made up of a substance they called aither or pempte ousia,
(5th essence). In Latin, this is Quinta Essentia.

This fifth essence or element was the fabled Philosopher's Stone - believed to cure all illness, extend life, and turn base metals into gold. How to combine the four elements to make the Fifth
was the dilemma of alchemy.